We have demonstrated an optofluidic Young Interferometer (YI) for real-time imaging of refractive index changes along the length of microchannels. We have also integrated electrophoresis with our YI to transport proteins in hydrogel filled microchannels while monitoring the movement of proteins in real-time. We are working to immobilise arrays of antibodies with specificity towards different analytes in the hydrogel filled channels, which when combined with electrophoresis integrated YI, will allow rapid, sensitive and multiplexed analysis.